基本信息:
- 专利标题： 包含度他雄胺和丙二醇單月桂酸酯的醫藥組成物及其製備方法
- 专利标题（英）：Pharmaceutical composition comprising dutasteride and propylene glycol monolaurate and preparation method of the same
- 专利标题（中）：包含度他雄胺和丙二醇单月桂酸酯的医药组成物及其制备方法
- 申请号：TW105144150 申请日：2016-12-30
- 公开(公告)号：TW201729815A 公开(公告)日：2017-09-01
- 发明人： 白泰坤 , BAIK, TAEGON , 金世延 , KIM, SEYEON , 安卿鎮 , AHN, KYEONGJIN , 金周姬 , KIM, JU-HEE , 朴映準 , PARK, YOUNG-JOON
- 申请人： 柳柳製藥股份有限公司 , YUYU PHARMA, INC. , 亞洲大學校產學協力團 , AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- 专利权人： 柳柳製藥股份有限公司,YUYU PHARMA, INC.,亞洲大學校產學協力團,AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- 当前专利权人： 柳柳製藥股份有限公司,YUYU PHARMA, INC.,亞洲大學校產學協力團,AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- 代理人： 洪澄文
- 优先权： 10-2015-0190815 20151231
- 主分类号： A61K31/58
- IPC分类号： A61K31/58 ; A61K47/34 ; A61K9/48
The present invention relates to a pharmaceutical composition comprising dutasteride and propylene glycol monolaurate, which improves the stability of dutasteride, which is a poorly soluble drug as a 5-alpha reductase inhibitor, and a process for its preparation. More particularly, the present invention also relates to a capsule formulation which is smaller in size than a commercial dutasteride capsule formulation (AVODART ®), but has the equivalent dissolution rate by preparing a pharmaceutical composition comprising propylene glycol monolaurate and dutasteride, which can improve the stability of the dutasteride. A dutasteride formulation having enhanced patients compliance and improved stability and a method for producing the same are provided.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/58 | ..含有杂环的，例如醛甾酮、炔羟雄烯唑、司坦唑、双季松龙、洋地黄皂甙配基 |