发明专利
TW200745158A 包含血細胞凝集素之組成物、製造其之方法與使用其之方法 COMPOSITIONS THAT INCLUDE HEMAGGLUTININ, METHODS OF MAKING AND METHODS OF USE THEREOF
审中-公开
基本信息:
- 专利标题： 包含血細胞凝集素之組成物、製造其之方法與使用其之方法 COMPOSITIONS THAT INCLUDE HEMAGGLUTININ, METHODS OF MAKING AND METHODS OF USE THEREOF
- 专利标题（英）：Compositions that include hemagglutinin, methods of making and methods of use thereof
- 专利标题（中）：包含血细胞凝集素之组成物、制造其之方法与使用其之方法 COMPOSITIONS THAT INCLUDE HEMAGGLUTININ, METHODS OF MAKING AND METHODS OF USE THEREOF
- 申请号：TW096107626 申请日：2007-03-06
- 公开(公告)号：TW200745158A 公开(公告)日：2007-12-16
- 发明人： 朗秋 尚 SONG, LANGZHOU , 弗利立安 納卡爾 NAKAAR, VALERIAN , 亞爾柏特E 普萊斯 PRICE, ALBERT E. , 琳達G 塔西 TUSSEY, LYNDA G. , 詹姆士W 胡利特 HULEATT, JAMES W. , 湯瑪斯J 普威爾 POWELL, THOMAS J. , 羅勃特K 伊凡斯 EVANS, ROBERT K.
- 申请人： 法克斯因內特公司 VAXINNATE CORPORATION
- 申请人地址： 美國
- 专利权人： 法克斯因內特公司 VAXINNATE CORPORATION
- 当前专利权人： 法克斯因內特公司 VAXINNATE CORPORATION
- 当前专利权人地址： 美國
- 代理人： 桂齊恆; 閻啓泰
- 优先权： 美國 60/779,854 20060307 美國 60/784,497 20060320 美國 60/790,457 20060407 美國 60/814,292 20060616 美國 60/830,881 20060714 美國 60/838,007 20060816 美國 60/856,451 20061103
- 主分类号： C07K
- IPC分类号： C07K ; A61K
Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.