基本信息:
- 专利标题： 免疫刺激性寡核酸 IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES
- 专利标题（英）：Immunostimulatory oligoribonucleotides
- 申请号：TW095143354 申请日：2006-11-23
- 公开(公告)号：TW200738877A 公开(公告)日：2007-10-16
- 发明人： 亞力山卓 佛斯巴赫 FORSBACH, ALEXANDRA , 裘格 弗莫 朱尼里斯 VOLLMER, JOERG , 葛萊森B. 里普佛德 LIPFORD, GRAYSON B.
- 申请人： 寇雷製藥公司 COLEY PHARMACEUTICAL GMBH , 寇雷製藥股份有限公司 COLEY PHARMACEUTICAL GROUP, INC.
- 申请人地址： 德國 美國
- 专利权人： 寇雷製藥公司 COLEY PHARMACEUTICAL GMBH,寇雷製藥股份有限公司 COLEY PHARMACEUTICAL GROUP, INC.
- 当前专利权人： 寇雷製藥公司 COLEY PHARMACEUTICAL GMBH,寇雷製藥股份有限公司 COLEY PHARMACEUTICAL GROUP, INC.
- 当前专利权人地址： 德國 美國
- 代理人： 桂齊恆; 閻啓泰
- 优先权： 美國 60/739,529 20051125 美國 60/778,989 20060303
- 主分类号： C12N
- IPC分类号： C12N ; A61K ; A61P
The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immnostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).