基本信息:
- 专利标题： 세르핀 융합 폴리펩타이드 및 이의 이용 방법
- 专利标题（英）：KR102231139B1 - Serpin fusion polypeptides and methods of use thereof
- 申请号：KR1020207005907 申请日：2012-06-28
- 公开(公告)号：KR102231139B1 公开(公告)日：2021-03-24
- 发明人： 익클먼,브랜든,피. , 타이머,존,씨. , 응우이,피터,엘. , 건터,그랜트,비. , 데브루,퀸
- 申请人： 인히브릭스, 인크.
- 申请人地址： ***** N. Torrey Pines Road, Suite ***, La Jolla, California *****, U.S.A.
- 专利权人： 인히브릭스, 인크.
- 当前专利权人： 인히브릭스, 인크.
- 当前专利权人地址： ***** N. Torrey Pines Road, Suite ***, La Jolla, California *****, U.S.A.
- 代理人： 특허법인다나
- 优先权： US61/502,055 2011-06-28; US61/570,394 2011-12-14; US61/577,204 2011-12-19; US61/638,168 2012-04-25
- 国际申请： PCT/US2012/044730 2012-06-28
- 国际公布： WO2013003641 2013-01-03
- 主分类号： C07K14/81
- IPC分类号： C07K14/81 ; C07K14/715 ; C07K16/24
摘要：
본발명은분자, 구체적으로폴리펩타이드, 더욱구체적으로세르핀폴리펩타이드또는세르핀유래아미노산서열및 적어도하나이상의 Fc 폴리펩타이드또는 Fc 폴리펩타이드유래아미노산서열; 사이토카인표적폴리펩타이드또는사이토카인표적폴리펩타이드유래서열; WAP 도메인포함폴리펩타이드또는 WAP 도메인포함폴리펩타이드유래서열; 및알부민폴리펩타이드또는혈청알부민유래아미노산서열을포함하는두 번째폴리펩타이드를포함하는융합단백질에관한것이다. 또한, 본발명은이러한분자들을다양한치료및 진단지표로이용하는방법뿐만아니라, 이러한분자를생산하는방법에관한것이다.
摘要（英）：
The present invention relates to a molecule, specifically a polypeptide, more specifically a serpin polypeptide or an amino acid sequence derived from a serpin, and at least one Fc polypeptide or an amino acid sequence derived from an Fc polypeptide; A sequence derived from a cytokine target polypeptide or a cytokine target polypeptide; A sequence derived from a polypeptide comprising a WAP domain or a polypeptide comprising a WAP domain; And a second polypeptide comprising an albumin polypeptide or an amino acid sequence derived from serum albumin. In addition, the present invention relates to methods of producing such molecules, as well as methods of using these molecules as various therapeutic and diagnostic indicators.