Systems and method for tile-based compression are disclosed. Image data, such as a frame, may be divided into tiles. The tiles may be sized based on a size of a line buffer. Tiles are compressed and decompressed individually. As portions of the image frame are updated, corresponding updated tiles may be compressed and stored. Likewise, as tiles are accessed they may be de-compressed and streamed to a requesting device. In some embodiments, a decoder operable to decompress tiles may be interposed between a memory device and a requesting device. Data encoding one or more compressed tiles may be grouped to enable decompression at a rate of four pixels per clock cycle. Methods for compressing image data including both RGB and RGB± components are disclosed.