基本信息:
- 专利标题： STING-작용제를 포함하는 세포외 소수포
- 申请号：KR20207029390 申请日：2019-03-22
- 公开(公告)号：KR20200141047A 公开(公告)日：2020-12-17
- 发明人： JANG SU CHUL , SIA CHANG LING , LEWIS NURUDDEEN D , HARRISON RANE A , MONIZ RAYMOND J , SATHYANARAYANAN SRIRAM , WILLIAMS DOUGLAS E , ECONOMIDES KYRIAKOS
- 申请人： CODIAK BIOSCIENCES INC
- 专利权人： CODIAK BIOSCIENCES INC
- 当前专利权人： CODIAK BIOSCIENCES INC
- 优先权： US201862647491 2018-03-23; US201862680501 2018-06-04; US201862688600 2018-06-22; US201862756247 2018-11-06; US201962822019 2019-03-21
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K31/7084 ; A61K35/37 ; A61K39/39 ; A61K45/06 ; A61K47/69 ; A61P29/00 ; A61P35/04 ; A61P37/00 ; C07K14/005 ; C07K16/28
摘要：
EV, 예를들어, 엑소좀을포함하는조성물, 캡슐화된 STING 작용제및 기재된상기조성물을제조하는방법이본원에서제공된다. 치료량의 EV, 예를들어, STING 작용제를캡슐화하는엑소좀의투여를통해면역반응을조절하는방법이또한본원에서제공된다. 면역반응은 IENβ반응또는골수수지상세포(mDC)의활성화일수 있다. STING 작용제를캡슐화하는엑소좀의투여를통해전신염증을유도하지않는면역반응을조절하는방법이또한본원에서제공된다.
摘要（英）：
Provided herein are compositions comprising EV, e.g., exosome, encapsulated STING agonists and methods of producing the compositions described. Also provided herein are methods of modulating an immune response via administration of a therapeutic amount of EV, e.g., exosomes encapsulating STING agonists. The immune response may be an ΙΕΝβ response or activation of myeloid dendritic cells (mDCs). Also provided herein are methods of modulating an immune response that does not induce systemic inflammation via administration of exosomes encapsulating STING agonists.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/50 | ..微型胶囊 |
| ------------A61K9/51 | ...毫微胶囊 |