The present application is continued anti- provides specific fusion polypeptide both, checkpoint PD-1 and LAG-3 may be useful in generating an infection reaction-tumor or anti. The fusion polypeptide can be used, for example, in many pharmaceutical applications as a cancer drug and / or immunomodulatory agent, or an anti-infectives for the treatment or prevention of human diseases such as a variety of tumors. The invention also relates to a method for producing the fusion polypeptides described herein and compositions comprising the fusion polypeptide. The invention also relates to a method for generating a nucleic acid molecule, and this fusion polypeptide and nucleic acid molecules encoding such a fusion polypeptide. Additionally, the present application discloses a composition, as well as therapeutic and / or diagnostic use of such fusion polypeptides include one or more such fusion polypeptides.