The residence structures, systems and methods are generally provided. In certain embodiments the retention structure is released prior to the particular time the subject to, the retention structure to be held in the position of the target object during (e.g., at least about 24 hours) (e. G., The patient) (e. G., Orally) It involves administering. Retention structure may be staying above structure in some cases. In some embodiments, the structures and systems described herein are in the active material of the high level (e.g., a therapeutic agent) high stability, the inner hole of the loading, the active material and / or the acidic environment of the device (e.g., wigang) the mechanical flexibility and strength, the object inside the hole to facilitate the passage through the GI tract until it is passed to (e.g., wigang), and / or physiological environment also / or of (e. g., intestinal environment) chemical irritant comprises one or more materials configured for rapid dissolution / decomposition of the reaction (e. g., intake of the solution that result in rapid dissolution / decomposition). In certain embodiments, the structure is controlled to determine the time out of a need to stay on the material that is configured for the controlled release of a therapeutic agent, a diagnostic agent and / or enhancing agents, is the loss of integrity of the stay-like structure is through the wigang and / or adjustable decomposition / structural material composed for dissolution and to combine, has a modular design. For example, in certain embodiments, the retention structure comprises a second element, and optionally a linker configured to emit a first resilient element, the active substance (e. G., Therapeutic agents). In some such embodiments, the linker is decomposed, separating the fracture after the residence time and the predetermined structure may be configured to be released from the internal position of the target object.
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Fig. 1e