基本信息:
- 专利标题： 이중 특이적 항체
- 专利标题（英）：Dual specific antibodies
- 专利标题（中）：双特异性抗体
- 申请号：KR1020167014866 申请日：2014-12-18
- 公开(公告)号：KR1020160099086A 公开(公告)日：2016-08-19
- 发明人： 푸,저메인 , 리,칭웨이,브이. , 쾨니그,패트릭
- 申请人： 제넨테크, 인크.
- 申请人地址： * DNA Way, South San Francisco, CA *****-****, USA
- 专利权人： 제넨테크, 인크.
- 当前专利权人： 제넨테크, 인크.
- 当前专利权人地址： * DNA Way, South San Francisco, CA *****-****, USA
- 代理人： 양영준; 이귀동
- 优先权： US61/919,552 2013-12-20; US61/946,547 2014-02-28
- 国际申请： PCT/US2014/071193 2014-12-18
- 国际公布： WO2015095539 2015-06-25
- 主分类号： C07K16/24
- IPC分类号： C07K16/24 ; C07K16/46 ; A61K39/395 ; A61K39/00
摘要：
본발명은이중특이적항체, 그리고이런항체를만들고이용하는방법을제공한다. 일반적으로, 이중특이적항체는정전또는소수성인경쇄가변영역 VL 잔기를갖는단일특이적항체를확인하고, 그리고단독으로또는상기항체의 VL을인코딩하는핵산서열의변경과합동으로상기항체의 VH에서하나또는그 이상의용매접근가능한잔기를인코딩하는핵산서열을변경함으로써산출된다. 변경된 VH와 VL이발현되고, 그리고이중특이적항체, 또는이들의항원결합단편이선별된다. 예시적인이중특이적항체뿐만아니라이들항체를이용하는방법역시제공된다.
摘要（英）：
The present invention provides a method making use of a bispecific antibody, and this antibody. In general, the bispecific antibodies are electrostatic or hydrophobic chain variable region confirmed that a single specific antibody having a VL residues and, and alone or in change with the incorporation of a nucleic acid sequence encoding the VL of the antibody in the VH of said antibody It is calculated by changing the nucleic acid sequence that encodes one or more solvent accessible residues. VH and VL expression is changed, and a bispecific antibody, or antigen-binding fragment thereof are selected. Exemplary bispecific antibodies as well as there is provided also a method of using these antibodies.
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/24 | ..抗细胞因子，淋巴因子或干扰素 |