The present invention is a drug, is particularly related to N- acetylcysteine ​​(NAC) surface-modified fracture customized implants and methods for their manufacture. In addition, the present invention relates to a drug delivery system, in particular the surface modification with gold nanoparticles (GNP) fracture customized implants and methods for their preparation. Fractures in accordance with the invention tailored implants that by coating the drug, in particular, N- acetylcysteine ​​(NAC) on the implant surface, effectively inhibit the inflammation of the fracture site, reduce the healing time by promoting bone formation and self-healing is possible there is an effect. In addition, drug delivery systems, in particular when by coating the gold nanoparticles (GNP) on the implant surface, exhibits a fracture site and high bone bonding coating in combination with various drugs, such as antioxidant, anti-inflammatory, bone formation, an excellent drug for insertion region It may represent the transfer effect.