基本信息:
- 专利标题： 섬유증의 치료를 위한 치환된 방향족 화합물 및 관련 방법
- 专利标题（英）：Substituted aromatic compounds and related method for the treatment of fibrosis
- 专利标题（中）：替代芳香化合物和相关方法治疗纤维化
- 申请号：KR1020157029293 申请日：2014-03-14
- 公开(公告)号：KR1020160051676A 公开(公告)日：2016-05-11
- 发明人： 자차리보울로스 , 애봇샤운 , 개그논린 , 라우린피에르 , 그로우익스브리지트
- 申请人： 프로메틱 파마 에스엠티 리미티드
- 申请人地址： Horizon Park, Barton Road, Comberton, Cambridge, United Kingdom CB** *AJ
- 专利权人： 프로메틱 파마 에스엠티 리미티드
- 当前专利权人： 프로메틱 파마 에스엠티 리미티드
- 当前专利权人地址： Horizon Park, Barton Road, Comberton, Cambridge, United Kingdom CB** *AJ
- 代理人： 제일특허법인
- 优先权： US61/798,269 2013-03-15
- 国际申请： PCT/CA2014/000236 2014-03-14
- 国际公布： WO2014138906 2014-09-18
- 主分类号： C07C57/30
- IPC分类号： C07C57/30 ; A61K31/192 ; C07C53/134 ; C07C57/58 ; C07C59/52
The present invention relates to a compound, or a pharmaceutically acceptable salt thereof represented by the formula; And it relates to compositions and methods using them containing them, which various fibrotic diseases of the lung fibrosis, liver fibrosis, skin fibrosis, kidney fibrosis, pancreatic fibrosis, systemic sclerosis, heart, including fibrosis or macular degeneration, the target object or It is for the prevention or treatment of conditions:
Wherein
A is C
5 alkyl, C
6 alkyl, C
5 alkenyl, C
6 alkenyl, C (O) - (CH
2)
n -CH
3 or CH (OH) - (CH
2)
n -CH
3, and;
R
1 is H, F or OH;
R
2 is C
5 alkyl, C
6 alkyl, C
5 alkenyl, C
6 alkenyl, C (O) - (CH
2)
n-CH
3, or CH (OH) - (CH
2)
n-CH
3, and;
R
3 is H, F, OH, or CH
2 and Ph;
R
4 is H, F or OH;
Q is
1) (CH
2)
m C (O) OH,
2) CH (CH
3) C (O) OH,
3) C (CH
3)
2 C (O) OH,
4) CH (F) -C (O) OH,
5) CF
2 -C (O) OH, or
6) C (O) -C (O) OH, and;
n is 3 or 4;
m is 1 or 2.