基本信息:
- 专利标题： ＡＭＦＲ-Ｆｃ 융합 단백질 및 이의 항암 용도
- 专利标题（英）：AMFR-Fc fusion protein and anti cancer uses thereof
- 专利标题（中）：AMFR-FC融合蛋白及其用途
- 申请号：KR1020140149772 申请日：2014-10-31
- 公开(公告)号：KR1020160050773A 公开(公告)日：2016-05-11
- 发明人： 강승훈 , 정한선 , 왕진상 , 양은희 , 전병욱 , 명제혁
- 申请人： 보령제약 주식회사
- 申请人地址： 서울특별시 종로구 창경궁로 *** (원남동)
- 专利权人： 보령제약 주식회사
- 当前专利权人： 보령제약 주식회사
- 当前专利权人地址： 서울특별시 종로구 창경궁로 *** (원남동)
- 代理人： 안소영
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/705 ; C07K16/00 ; C12N15/62 ; A61K38/17 ; A61P35/00
摘要：
본발명은 AMFR (Autocrine motility factor receptor) 단백질과인간면역글로불린 Fc 영역이융합된 AMFR-Fc 융합단백질및 이의암 예방또는치료용도에관한것이다. 본발명에따른 AMFR-Fc 융합단백질은위암, 유방암등 각종암조직에서 AMF의과발현에의해유도되는암세포의증식을효과적으로억제함으로써, 각종암에대하여우수한암 예방또는치료효과를나타낸다.
摘要（中）：
本发明涉及自分泌运动因子受体（AMFR）蛋白和人免疫球蛋白Fc区融合在一起的AMFR-Fc融合蛋白。 本发明还涉及其用于预防或治疗癌症的用途。 根据本发明，AMFR-Fc融合蛋白有效抑制由胃癌和乳腺癌各种癌组织中过表达自分泌运动因子（AMF）诱导的癌细胞的增殖，从而表现出预防或治疗各种 癌症。
摘要（英）：
The invention AMFR (Autocrine motility factor receptor) protein and a human immunoglobulin Fc domain fused AMFR-Fc fusion protein and its use in the prevention or treatment of cancer relates will. AMFR-Fc fusion protein according to the present invention shows a superior prophylactic or therapeutic effect against cancer by effectively inhibiting the proliferation of cancer cells induced by the overexpression of the AMF in various cancer tissues, including stomach cancer, breast cancer, a variety of cancers.