基本信息:
- 专利标题： 항종양 활성이 있는 신규 결합 분자
- 专利标题（英）：Novel binding molecules with antitumoral activity
- 专利标题（中）：具有抗肿瘤活性的新型结合分子
- 申请号：KR1020147029084 申请日：2013-03-08
- 公开(公告)号：KR1020140135251A 公开(公告)日：2014-11-25
- 发明人： 브락,사이먼 , 무어란,프레데릭 , 토레르,이사벨라 , 우즈,리차드 , 베르트슁어,율리안 , 그라불로브스키,드라간 , 샤데,바베트 , 클룹쉬,크리스티나 , 하헤미,헬렌
- 申请人： 코바겐 아게
- 申请人地址： Wagistrasse **, CH-****, Schlieren, Switzerland
- 专利权人： 코바겐 아게
- 当前专利权人： 코바겐 아게
- 当前专利权人地址： Wagistrasse **, CH-****, Schlieren, Switzerland
- 代理人： 특허법인다나
- 优先权： EP121599385 2012-03-16
- 国际申请： PCT/EP2013/054768 2013-03-08
- 国际公布： WO2013135588 2013-09-19
- 主分类号： C07K16/32
- IPC分类号： C07K16/32 ; C07K16/46 ; A61K39/395 ; A61P35/00
The present invention relates to a binding molecule that specifically binds to two different epitopes of the antigen that is expressed in tumor cells, the binding molecules, including the following: (a) a first epitope of an antigen which is expressed in the tumor cells a first coupling (poly) peptide specifically binding to said first binding (poly) peptides derived from polypeptides of Fyn SH3- first binding (poly) peptides; And (b) a second binding (poly) peptide specifically binding to a second epitope of the antigen expressed on the tumor cells. The present invention also provides a host cell or non-transformed with a vector and the vector comprising the nucleic acid molecule, the nucleic acid molecules encoding binding molecules of the present invention relates to a human host. The invention also relates to a method for producing a binding molecule of the invention and pharmaceutical and diagnostic compositions. Furthermore, the invention also relates to the use of the binding molecules, tumor treatment of a nucleic acid molecule, vector or host cell of the present invention.
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K16/00 | 免疫球蛋白，例如，单克隆或多克隆抗体 |
| --------C07K16/18 | .来自动物或人的抵抗物质 |
| ----------C07K16/32 | ..抗致肿瘤基因的转移产物 |