基本信息:
- 专利标题： TGFBI를 이용한 패혈증 진단용 조성물 및 이를 이용한 패혈증 예방 또는 치료용 약학적 조성물과 이의 스크리닝 방법
- 专利标题（英）：Diagnostic composition for sepsis using TGFBI and pharmaceutical composition for preventing or treating of sepsis using the same and screening method thereof
- 专利标题（中）：使用TGFBI和药物组合物治疗用于预防或治疗食欲的诊断组合物及其筛选方法
- 申请号：KR1020130054969 申请日：2013-05-15
- 公开(公告)号：KR1020140134923A 公开(公告)日：2014-11-25
- 发明人： 배종섭 , 김인산 , 이원화 , 김신우
- 申请人： 경북대학교 산학협력단
- 申请人地址： 대구광역시 북구 대학로 ** (산격동, 경북대학교)
- 专利权人： 경북대학교 산학협력단
- 当前专利权人： 경북대학교 산학협력단
- 当前专利权人地址： 대구광역시 북구 대학로 ** (산격동, 경북대학교)
- 代理人： 이희숙; 김석만
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/68 ; C12N15/11
The present invention relates to sepsis diagnostic composition and the pharmaceutical composition and its screening method for sepsis preventing or treating by Using TGFBI, more particularly TGFBI protein expression levels measured sepsis prophylaxis composition screening methods for using, the TGFBI inhibitor composition for the treatment of sepsis, including, TGFBI protein expression levels sepsis diagnostic composition comprising a measurement preparation, or the like relates diagnosis kit, diagnosis method. TGFBIp is reducing the expression of TGFBIp to increase significantly, when sepsis occurred, can reduce mortality, the permeability of vascular endothelial cells due to sepsis. Therefore, by using the TGFBIp can be screened for sepsis treatment, can be prepared a pharmaceutical composition for preventing or treating sepsis by TGFBIp inhibitor, it is effective in diagnosing sepsis by measuring the expression level of the protein TGFBI.