基本信息:
- 专利标题： ＣＤ１３８을 타겟팅하는 면역접합체의 용도
- 专利标题（英）：Uses of immunoconjugates targeting cd138
- 专利标题（中）：使用免疫球蛋白靶向CD138
- 申请号：KR1020147018841 申请日：2012-12-07
- 公开(公告)号：KR1020140100571A 公开(公告)日：2014-08-14
- 发明人： 슐츠그레거 , 오스터로스프랑크 , 해더토마스 , 브루에쉐어크리스토프 , 니에만가브리엘르 , 잉글링안드레 , 우헤렉크리스토프 , 다엘켄벤야민 , 와르텐버그-디맨드안드레아 , 주베르찬탈 , 구트쉐르마르쿠스 , 베르노에스터카트린 , 쾨니히마틴
- 申请人： 바이오테스트 아게 , 이뮤노젠 아이엔씨
- 申请人地址： Landsteinerstrasse *, D-***** Dreieich, Germany
- 专利权人： 바이오테스트 아게,이뮤노젠 아이엔씨
- 当前专利权人： 바이오테스트 아게,이뮤노젠 아이엔씨
- 当前专利权人地址： Landsteinerstrasse *, D-***** Dreieich, Germany
- 代理人： 유미특허법인
- 优先权： US61/568,640 2011-12-08; US61/722,367 2012-11-05
- 国际申请： PCT/EP2012/074867 2012-12-07
- 国际公布： WO2013083817 2013-06-13
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K47/48 ; A61P35/00
The present invention provides a method for treating a disease associated with target cells expressing CD138, CD138 comprising one or more engineered targeting antibody, and one or more operator molecules to target expressing cells, the operation on said operation-targeted antibody-party molecules that the immunoconjugate is functionally attached to the formed, comprising an object, in particular the method comprising administering to a human subject in need thereof, preferably at least a portion of the engineered targeting antibody and give it the IgG4 isotype characteristic, the immunoconjugates is doedoe administered in multidose medication usage, including administration twice or more, the maximum allowable total dose to be administered during the active treatment cycle, the total capacity (AMTD) or a or a part of AMTD, the AMTD and / or a part amount of the AMTD immune the light is administered in a single dose comprising administering a conjugate as part of a multiple single dose usage To be higher than the capacity to cause the dose limiting toxicity (DLT), or, and / or the maximum allowable capacity in the case of administering the immunoconjugate as a single dose comprising administering as part of a multiple single dose usage in the active treatment cycles ( It provides therapy characterized in that is higher than the MTD).
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/395 | .抗体；免疫球蛋白；免疫血清，例如抗淋巴细胞血清 |