基本信息:
- 专利标题： ＴＯＰＫ 펩티드 및 이를 포함하는 백신
- 专利标题（英）：Topk peptides and vaccines including the same
- 专利标题（中）：TOPK PEPTIDES和疫苗，包括它们
- 申请号：KR1020147014201 申请日：2012-10-25
- 公开(公告)号：KR1020140085565A 公开(公告)日：2014-07-07
- 发明人： 나카무라유스케 , 츠노다타쿠야 , 오사와류지 , 요시무라사치코 , 와타나베토모히사 , 나카야마가쿠
- 申请人： 온코세라피 사이언스 가부시키가이샤
- 申请人地址： *-*, Sakado *-chome, Takatsu-ku, Kawasaki-shi, Kanagawa***-****, Japan
- 专利权人： 온코세라피 사이언스 가부시키가이샤
- 当前专利权人： 온코세라피 사이언스 가부시키가이샤
- 当前专利权人地址： *-*, Sakado *-chome, Takatsu-ku, Kawasaki-shi, Kanagawa***-****, Japan
- 代理人： 이원희
- 优先权： US61/552,817 2011-10-28
- 国际申请： PCT/JP2012/006853 2012-10-25
- 国际公布： WO2013061594 2013-05-02
- 主分类号： C07K7/00
- IPC分类号： C07K7/00 ; C12N5/10 ; C12N15/09 ; G01N33/574 ; A61K38/00 ; A61P35/00
As discussed in more detail herein, the epitope (epitope) peptides derived from TOPK and the immunogenic fragment having the ability to induce cytotoxic T cells (CTL) and therefore more specifically, are suitable for use in cancer immunotherapy. Peptide to the peptide of the present invention comprises a modified amino acid having a TOPK derived amino acid sequences and their modified versions, namely one, two, or several amino acids are substituted (), deletion (), inserted and / or added in the CTL induction It encompasses everything. In addition, as well as poly-lactide tube nucleoside in which the peptides no encryption provides a pharmaceutical composition comprising the peptide or any polynucleotide. Peptides, polynucleotides, and pharmaceutical compositions of the present invention in either or both the treatment and prevention of cancers and tumors found a particular utility.
公开/授权文献:
- KR102020491B1 ＴＯＰＫ 펩티드 및 이를 포함하는 백신 公开/授权日：2019-09-10