基本信息:
- 专利标题： 생물학적 물질용 저장 안정화 건조 조성물
- 专利标题（英）：Dry storage stabilizing composition for biological materials
- 专利标题（中）：用于生物材料的干燥储存稳定组合物
- 申请号：KR1020137006461 申请日：2011-08-12
- 公开(公告)号：KR1020140019766A 公开(公告)日：2014-02-17
- 发明人： 하렐,모티 , 탕,충
- 申请人： 어드밴스드 바이오뉴트리션 코프.
- 申请人地址： **** Columbia Gateway Drive, Columbia, MD *****-****, USA
- 专利权人： 어드밴스드 바이오뉴트리션 코프.
- 当前专利权人： 어드밴스드 바이오뉴트리션 코프.
- 当前专利权人地址： **** Columbia Gateway Drive, Columbia, MD *****-****, USA
- 代理人： 특허법인 남앤드남
- 优先权： US61/373,711 2010-08-13
- 国际申请： PCT/US2011/047547 2011-08-12
- 国际公布： WO2012021783 2012-02-16
- 主分类号： A23L3/40
- IPC分类号： A23L3/40 ; A23L3/3463 ; C12N1/00 ; C12N7/01 ; A23J3/30 ; A23L1/00 ; A23K1/00 ; A23P1/00
The present invention is a composition and drying method for preserving sensitive biologically active material, such as a storage during the peptide, protein, hormone, nucleic acid, antibody, drug vaccine, yeast, bacteria (probiotics or other), the virus and / or cell suspension It includes. The composition and the carbohydrate component comprises a glass reinforcing agent components, wherein the carbohydrate component comprises a mixture of disaccharides, oligosaccharides and polysaccharides and glass reinforcing agent comprises an ion of an organic acid and a protein hydrolyzate. It is prepared by freezing to form a small bead, a string or a drip-composition is dispersed in the solution of all the solid components were rapidly. The preferred drying method of the frozen beads, strings or infusion is initiated by a short purging and structural stabilization of the particle frozen to a vacuum pressure of less than 2000 mTORR followed by a primary drying step at a temperature that is desired for vacuum pressure of 2000 mTORR exceeded. While the secondary and final drying step of a material, a sufficient vacuum pressure and elevated temperature are applied to the final desired water activity of the dried material it is achieved.
公开/授权文献:
- KR101863920B1 생물학적 물질용 저장 안정화 건조 조성물 公开/授权日：2018-06-01