基本信息:
- 专利标题： 제약 조합물
- 专利标题（英）：Pharmaceutical combinations
- 专利标题（中）：药物组合
- 申请号：KR1020137008528 申请日：2011-10-03
- 公开(公告)号：KR1020130108330A 公开(公告)日：2013-10-02
- 发明人： 첸,얀 , 황,시중 , 머피,레온 , 니펠러,비트
- 申请人： 노파르티스 아게
- 申请人地址： Lichtstrasse **, CH-**** Basel, Switzerland
- 专利权人： 노파르티스 아게
- 当前专利权人： 노파르티스 아게
- 当前专利权人地址： Lichtstrasse **, CH-**** Basel, Switzerland
- 代理人： 양영준; 위혜숙
- 优先权： US61/389,445 2010-10-04
- 国际申请： PCT/US2011/054536 2011-10-03
- 国际公布： WO2012047775 2012-04-12
- 主分类号： A61K31/4188
- IPC分类号： A61K31/4188 ; A61K31/4745 ; A61P35/00
The invention (a) a catalytic mTOR inhibitor, for example, imidazo-quinoline derivatives of phosphatidylinositol-3-kinase catalytic (PI3K) and the mTOR inhibitor compound, and (b) at least one allosteric mTOR inhibitor compound, and optionally comprising at least one pharmaceutically acceptable carrier, in particular a mammalian target rapamycin (mTOR) at the same time for the treatment of kinase dependent proliferative diseases, individually or as a pharmaceutical combination for sequentially used; And the combination of use in the treatment of mTOR kinase dependent proliferative diseases; Pharmaceutical compositions comprising said combination; The combination of water usage in the manufacture of a medicament for treating a proliferative disease; At the same time, a commercial package or product comprising the combination as a combined preparation for separate use or as a sequence; And warm-blooded animals, in particular, to human therapy.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/415 | ....1,2二唑 |
| ----------------A61K31/4188 | .....与杂环稠合的，例如生物素、索比尼尔 |