基本信息:
- 专利标题： 약학적 활성 펩티드로 치료할 수 있는 증상을 치료하기 위한 약학적 조성물 및 포장 제형
- 专利标题（英）：A pharmaceutical composition for the treatment of a condition treatable with a pharmaceutical active peptide and a packaged formulation
- 专利标题（中）：用于治疗可用药物活性肽和包装配方治疗的条件的药物组合物
- 申请号：KR1020117025543 申请日：1997-12-11
- 公开(公告)号：KR1020110122773A 公开(公告)日：2011-11-10
- 发明人： 게프터말콤엘 , 바커니콜라스 , 무쏘게리 , 몰리니욱스크리스토퍼제이
- 申请人： 프래시스 파마슈티컬즈 인코포레이티드
- 申请人地址： 미국 메사츄세츠 ***** 캠브리지 원 햄프셔 스트리트
- 专利权人： 프래시스 파마슈티컬즈 인코포레이티드
- 当前专利权人： 프래시스 파마슈티컬즈 인코포레이티드
- 当前专利权人地址： 미국 메사츄세츠 ***** 캠브리지 원 햄프셔 스트리트
- 代理人： 황광현
- 优先权： US08/762,747 1996-12-11
- 国际申请： PCT/US1997/022881 1997-12-11
- 国际公布： WO1998025642 1998-06-18
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K9/14 ; A61K38/10 ; A61K38/08
The present invention is a peptide compound, for example, peptides, polypeptides, protein, peptide analogues (peptidomimetic), etc.] relates to a sustained-release formulation containing a water-insoluble complex composed of a carrier and a polymer. Formulations of the present invention is possible that the peptide compound loaded into the small volume and enables a long period of time, for example the transport of pharmaceutically active peptide compound for one month after administration of the complex. Complexes of the invention can be milled or crushed to a fine powder. In powder form, suitable for complexing the scan, it is possible to form a stable suspension and dispersion. In a preferred embodiment, the peptide compound of the complex has LHRH analogue, preferably an LHRH antagonist, the carrier polymer is an anionic polymer, preferably carboxymethylcellulose. In another aspect, the present invention LHRH- analogs for the treatment of treatable with LHRH analogue-to a method using a composition containing the complex and method of manufacturing the composite of this invention.
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K47/00 | 以所用的非有效成分为特征的医用配制品，如载体、惰性添加剂 |
| --------A61K47/48 | .非有效成分被化学键键合到有效成分上，例如聚合物药物轭合物 |