基本信息:
- 专利标题： 신규한 암 치료 표적인 ＰＲＰＦ４ 단백질의 발현 또는 활성 억제제를 포함하는 암 치료 또는 암 전이 억제용 약학적 조성물
- 专利标题（英）：Pharmaceutical composition for the treatment of cancers or inhibition of metastasis containing the expression or activity inhibitors of prpf4, a novel cancer therapeutic target
- 专利标题（中）：用于治疗癌症或抑制含有PRPF4的表达或活性抑制剂的METASTASIS的药物组合物，一种新型癌症治疗目标
- 申请号：KR1020100034717 申请日：2010-04-15
- 公开(公告)号：KR1020110115296A 公开(公告)日：2011-10-21
- 发明人： 권기선 , 김선영 , 최소영 , 도소희 , 주성규 , 박성섭
- 申请人： 한국생명공학연구원
- 申请人地址： ***, Gwahak-ro, Yuseong-gu, Daejeon, (***-***), Republic of Korea
- 专利权人： 한국생명공학연구원
- 当前专利权人： 한국생명공학연구원
- 当前专利权人地址： ***, Gwahak-ro, Yuseong-gu, Daejeon, (***-***), Republic of Korea
- 代理人： 이원희
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P35/00 ; A61K31/7105 ; A61K31/711
The present invention relates to treating cancer or pharmaceutical composition for cancer metastasis suppressor comprising the expression or activity inhibitor for the PRPF4 protein novel cancer therapeutic target as an active ingredient, to specifically establish a large-scale gene expression database of human cancer tissues data was discovering novel targeted anti-cancer candidate target by mining techniques, which on the basis of gene expression profiles in cancer cell lines, selection of a suitable cancer cell lines were experimentally verified by the inhibition of the target candidate gene, PRPF4 the colon through which , and over-expression in cancer tissues and the cancer cells such as lung cancer and breast cancer, by being of cancer cell growth, migration, invasion and metastasis is inhibited induced cell death by inhibition of PRPF4, evaluator has confirmed the potential of PRPF4 as a target of the novel anti-cancer agents , inhibitors of expression or activity PRPF4 protein may be used in the treatment of cancer or cancer metastasis is useful as an active ingredient of a pharmaceutical composition for the inhibition.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/16 | .含有20个以上氨基酸的肽；胃泌激素；生长素抑制素；促黑激素；其衍生物 |