基本信息:
- 专利标题： 알파-갈락토실 세라미드 유사체, 및 면역요법제, 아주반트, 및 항바이러스제, 항박테리아제, 및 항암제로서의 그의 용도
- 专利标题（英）：Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and intiviral, antibacterial, and anticancer agents
- 专利标题（中）：ALPHA-GALACTOSYL CERAMIDE ANALOGS及其作为免疫抑制剂，ADJUVANTS和抗生素，抗生素和抗原剂的用途
- 申请号：KR1020117003339 申请日：2009-07-10
- 公开(公告)号：KR1020110107317A 公开(公告)日：2011-09-30
- 发明人： 옹,치-후에이 , 유,앨리스 , 창,야-젠 , 린,쿤-시엔 , 쳉,와이.에스.,에드몬드 , 잔,지아-츠롱 , 린,이-링 , 훙,중-퉁
- 申请人： 아카데미아 시니카
- 申请人地址： *** Academia Road, Section *, Nankang, Taipei *****, Taiwan
- 专利权人： 아카데미아 시니카
- 当前专利权人： 아카데미아 시니카
- 当前专利权人地址： *** Academia Road, Section *, Nankang, Taipei *****, Taiwan
- 代理人： 양영준; 양영환
- 优先权： US12/218,082 2008-07-11
- 国际申请： PCT/US2009/050328 2009-07-10
- 国际公布： WO2010006315 2010-01-14
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K39/39 ; A61P35/00 ; A61P31/04
The present invention synthesis of alpha-relates to their use as galactosyl ceramide chamber (α-GalCer) analogs, and immune therapy go agents, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject is at least one lymphocyte and at least one antigen-presenting compound an effective amount of a subject with acquired immune system represented by the structure of formula (I) containing a population of cells, including cells or a the method comprising administering a pharmaceutically acceptable salt thereof; To form a complex between the presenting cell, wherein the formation of the complex activating the receptor on lymphocytes, said compound and the antigen; And activating the lymphocyte comprises a step of generating a cytokine reaction.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/70 | .碳水化合物；糖；其衍生物 |