基本信息:
- 专利标题： 글루카곤 유사 펩티드-2(ＧＬＰ-2) 유사체
- 专利标题（英）：Glucagon-like-peptide-2(glp-2)
- 申请号：KR1020117015195 申请日：2006-05-04
- 公开(公告)号：KR1020110093924A 公开(公告)日：2011-08-18
- 发明人： 라르센비야르네듀 , 페테르센이베테미아타 , 에베회즈커스텐
- 申请人： 질랜드 파마 에이/에스
- 申请人地址： Smedeland **, DK-**** Glostrup, Denmark
- 专利权人： 질랜드 파마 에이/에스
- 当前专利权人： 질랜드 파마 에이/에스
- 当前专利权人地址： Smedeland **, DK-**** Glostrup, Denmark
- 代理人： 강승옥; 김성기
- 优先权： US60/678,066 2005-05-04
- 国际申请： PCT/GB2006/001633 2006-05-04
- 国际公布： WO2006117565 2006-11-09
- 主分类号： C07K14/605
- IPC分类号： C07K14/605 ; A61K38/26 ; A61P1/00
[HGly2] it includes one or more substitutions compared to the GLP-2 and improve its biological activity in vivo and / or, for example, GLP-2 analogs for improving chemical stability, as evaluated in the stability analysis in vitro is disclosed do. More specifically, the present in some cases preferred GLP-2 analogues disclosed herein are (as mentioned in the introduction) position 2 and position 3, 5, 7, 10 and at least one further substitution at 11, and / or amino acid 31 to 33 amino acid deletion of one or more of, and / or N- terminal or contain one or more substitutions at positions 8, 16, 24 and / or 28 of the C- terminal wild-type GLP-2 sequence with the addition of a stabilizing peptide sequence do. The analogues are particularly useful for improving the side effect of prevention or treatment, and chemotherapy in the above chapter, and related disorders.
公开/授权文献:
- KR101242951B1 글루카곤 유사 펩티드-2(ＧＬＰ-2) 유사체 公开/授权日：2013-03-13
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/415 | .来自植物 |
| ----------C07K14/44 | ..来自原生动物门 |
| ------------C07K14/605 | ...高血糖素 |