基本信息:
- 专利标题： ＰＡＩ―１ 작용의 치료학적 억제제 및 이의 사용 방법
- 专利标题（英）：Therapeutic inhibitors of pai-1 function and methods of their use
- 专利标题（中）：PAI-1功能的治疗抑制剂及其使用方法
- 申请号：KR1020107017701 申请日：2009-01-09
- 公开(公告)号：KR1020100129271A 公开(公告)日：2010-12-08
- 发明人： 리드,토마스,디. , 피터슨,리차드,이. , 리드,찰스,씨. , 마짜렐리소피친스키,조안 , 메러닉,베타니,엘. , 칼슨,조나단 , 배어,캐써린,엘. , 타세바,엘레나
- 申请人： 인트렉손 코포레이션
- 申请人地址： **** Kraft Drive, Suite ****, Blacksburg, VA *****, USA
- 专利权人： 인트렉손 코포레이션
- 当前专利权人： 인트렉손 코포레이션
- 当前专利权人地址： **** Kraft Drive, Suite ****, Blacksburg, VA *****, USA
- 代理人： 손민
- 优先权： US61/020,137 2008-01-09; US61/080,640 2008-07-14
- 国际申请： PCT/US2009/000155 2009-01-09
- 国际公布： WO2009089059 2009-07-16
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C12N15/12 ; A61K38/17 ; A61P9/00
The present invention relates to mammalian PAI-Ⅰ ligands and modulators. In particular, the invention relates to polynucleotides coding for the polypeptides, polypeptide compositions and polypeptide ligands and / or modulators of PAI-1. The present invention relates to a homopolypropylene ligand (homopolyligand) or poly heteropoly ligand ligand (heteropolyligand) for adjusting the PAI-Ⅰ activity. The invention also relates to a ligand and ligand poly goods station to the area of the cell. The invention also relates to localization stator (tether), and the promoter sequence can be used to provide spatial control of the PAI-Ⅰ ligand and poly ligand. The invention also relates to PAI-Ⅰ ligand and poly inducible gene switch (gene switch) that can be used to provide a temporary adjustment of the ligand. The invention also relates to a method for treating or preventing atherosclerosis. The invention also relates to a method for treating or preventing fibrosis.
公开/授权文献:
- KR101712208B1 ＰＡＩ―１ 작용의 치료학적 억제제 및 이의 사용 방법 公开/授权日：2017-03-03