基本信息:
- 专利标题： 간암 마커로서의 ＬＣＮ2 유전자, 단백질 및 간암 진단키트
- 专利标题（英）：Lipocalin 2 as a tumor associated marker of hepatocellular carcinoma and a hepatocellular carcinoma diagnostic kit using thereof
- 专利标题（中）：LIPOCALIN 2作为肿瘤相关标记的肝细胞癌和使用其的肝细胞癌诊断试剂盒
- 申请号：KR1020070094494 申请日：2007-09-18
- 公开(公告)号：KR1020090029338A 公开(公告)日：2009-03-23
- 发明人： 송은영 , 박미영 , 이향신 , 이희구 , 김재화 , 최인성 , 김대광 , 김대곤 , 유경란 , 박해준 , 염영일
- 申请人： 한국생명공학연구원 , 전북대학교산학협력단
- 申请人地址： ***, Gwahak-ro, Yuseong-gu, Daejeon, (***-***), Republic of Korea
- 专利权人： 한국생명공학연구원,전북대학교산학협력단
- 当前专利权人： 한국생명공학연구원,전북대학교산학협력단
- 当前专利权人地址： ***, Gwahak-ro, Yuseong-gu, Daejeon, (***-***), Republic of Korea
- 代理人： 양부현; 강성혜
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/53
摘要：
A hepatocellular carcinoma diagnostic kit containing a lipocalin 2 gene or their fraction and antibody is provided to increase the accuracy of the liver cancer diagnosis by performing the analysis by using the overexpression phenomenon of LCN2 in tissue, cells or body fluid of hepatocellular carcinoma patients. A hepatocellular carcinoma diagnostic kit comprises an antibody which is specifically bonded with the LCN2 protein. The hepatocellular carcinoma diagnostic kit comprises SEQ ID NO:3 which is specifically bonded with LCN2 mRNA or the nucleotide of SEQ ID NO:4. The hepatocellular carcinoma is diagnosed with the increment of the LCN2 protein amount. The mRNA quantity detection method uses RT-PCR(Reverse transcription polymerase chain reaction), competitive RT-PCR, realtime RT-PCR, RNase protection assay, Nothern blotting or DNA chip.
摘要（中）：
提供含有脂质运载蛋白2基因或其部分和抗体的肝细胞癌诊断试剂盒，通过使用LCN2在肝细胞癌患者的组织，细胞或体液中的过表达现象进行分析，提高肝癌诊断的准确性。 肝细胞癌诊断试剂盒包括与LCN2蛋白特异性结合的抗体。 肝细胞癌诊断试剂盒包含与LCN2 mRNA特异性结合的SEQ ID NO：3或SEQ ID NO：4的核苷酸。 诊断为肝细胞癌的LCN2蛋白量增加。 mRNA量检测方法采用RT-PCR（逆转录聚合酶链反应），竞争性RT-PCR，实时RT-PCR，RNA酶保护试验，Nothern印迹法或DNA芯片。
公开/授权文献:
- KR100948808B1 간암 마커로서의 ＬＣＮ2 유전자, 단백질 및 간암 진단키트 公开/授权日：2010-03-24