基本信息:
- 专利标题： 뉴블라스틴 변형체
- 专利标题（英）：Neublastin variants
- 专利标题（中）：NEUBLASTIN VARIANTS
- 申请号：KR1020077005926 申请日：2005-08-18
- 公开(公告)号：KR1020070050964A 公开(公告)日：2007-05-16
- 发明人： 로소만도안토니 , 실비안로라 , 페핀스키알.블레이크
- 申请人： 바이오젠 엠에이 인코포레이티드
- 申请人地址： *** Binney Street, Cambridge, MA *****, U.S.A.
- 专利权人： 바이오젠 엠에이 인코포레이티드
- 当前专利权人： 바이오젠 엠에이 인코포레이티드
- 当前专利权人地址： *** Binney Street, Cambridge, MA *****, U.S.A.
- 代理人： 김진회; 강승옥
- 优先权： US60/602,825 2004-08-19; US60/694,067 2005-06-24
- 国际申请： PCT/US2005/029637 2005-08-18
- 国际公布： WO2006023781 2006-03-02
- 主分类号： A61K38/17
- IPC分类号： A61K38/17
摘要：
Variant Neublastin polypeptides having substitutions at selected amino acid residues are disclosed. Substitution at one or more selected amino acid residues decreases heparin binding and increases serum exposure of variant Neublastin polypeptides. Also disclosed are methods of using variant Neublastin polypeptides to treat disorders and activate the RET receptor in a mammal.
摘要（英）：
The present invention relates to a selected amino acid residues was substituted New vinblastine polypeptide. Which replaced the one or more selected amino acid variations New vinblastine reduced heparin-binding polypeptides and increased serum exposure. In addition, the present invention is treating diseases in mammals, and relates to the use of the modified polypeptide New vinblastine for activating the RET receptor. New vinblastine, nervous system, polypeptides, RET receptor
公开/授权文献:
- KR101215697B1 뉴블라스틴 변형체 公开/授权日：2012-12-28
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/04 | .在完全确定的序列中最多有20个氨基酸的肽；其衍生物 |
| ----------A61K38/17 | ..来源于动物；来源于人类 |