The present invention relates to a Helicobacter pylori strain and methods of using the same antigen as an antigen suitable for the production of diagnostic reagents and vaccines to determine whether Helicobacter pylori (Helicobacter pylori) infection in Korean. Helicobacter pylori strain suitable as an antigen for producing in the present invention are ① standard Monarch (ACTC strain) and RFLP (restriction fragment length polymorphism) type separations, exhibits a protein expression pattern and antigenic shows the specificity of Korea separation weeks, ② growth faster to facilitate the mass production of cells suitable for use in antigen-producing strain, ③ vacuole formation cytotoxin, probably play an important role in ulcer formation (vacuolating cytotoxin, Vac a) and cytotoxin associated protein (cytotoxin-associated gene a expressing the protein, Cag a) and, ④ the two strains isolated from patients with a 1-week of each ill be divided into chronic gastritis and peptic ulcer. The two combined crushing approximately prepared mixture of strains may be used as the H. pylori antigen for the manufacture diagnostic reagents and vaccines targeting Koreans.