The invention The present invention required for palmitate tick amide, Lai bovine phosphatidylcholine, dihydro ratio off aminopterin and before high blood pressure or hypertension, prevention, improvement or screening method for a therapeutic agent, before high blood pressure or diagnosis or prognosis of hypertension with Lp-PLA ₂ activity It relates to a method for providing information and diagnostic kits. According to the invention, around the plasma palmitoleic tick amide, Lai bovine phosphatidylcholine and bar, the plasma metabolism of Lp-PLA have reduced levels of the _second activity, increase the level of dihydro ratio off aminopterin in the one subject administered an anti-hypertensive agent body and using the Lp-PLA ₂ activity change can be the screening of the entire blood pressure or hypertension, prevention, improvement or treatment. In addition, blood pressure increase and palmitate tick amide, Lai predetermined level and the Lp-PLA ₂ activity of phosphatidyl choline has a positive correlation, dihydro ratio level of the bar the plasma metabolite having the negative correlation level and the off-aminopterin or by analyzing the Lp-PLA ₂ activity there is an effect that can be usefully used in the diagnosis of the entire blood pressure or high blood pressure.