The present invention relates to a compound or a pharmaceutically acceptable salt thereof of formula (II) to

[Wherein, (a) is selected from the group consisting of lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy - lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, mono (lower alkyl) amino, di (lower alkyl) amino, mono (lower alkenyl) amino, di (lower alkenyl) amino, lower alkoxycarbonyl amino, lower alkylcarbonylamino, from (in conjunction substituents to form a heterocyclic keurilreul together with the nitrogen in nitrogen), lower alkylcarbonyl, carboxy, lower 15 alkoxy, cyano, halogen and nitro-substituted amino substituted with one or two additional substituents selected independently or unsubstituted divalent residue of benzene (two adjacent substituents which may be a methylenedioxy); Or lower alkyl, lower alkoxy, lower alkoxy - optionally substituted with one or two substituents selected from lower alkyl, or halogen-lower alkoxy, amino, (lower alkyl, lower alkenyl and alkylcarbonyl, halo -20 lower alkyl, lower alkoxy search) a substituted or unsubstituted divalent group represents a pyridine moiety (Z = N); R ¹ is hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl represents, R ² is (b), (c) and represents a group selected from (d)].