基本信息:
- 专利标题： 펩티드 티오에스테르체의 제조방법
- 专利标题（英）：Process for production of peptide thioester
- 专利标题（中）：肽硫酯生产工艺
- 申请号：KR1020127001146 申请日：2010-06-21
- 公开(公告)号：KR101676515B1 公开(公告)日：2016-11-15
- 发明人： 가지하라야스히로 , 오카모토료 , 사카모토이즈미 , 이시이가즈유키
- 申请人： 가부시키가이샤 도우사 고가쿠 겐큐쇼
- 申请人地址： ***, Chudoji-minamimachi, Shimogyo-ku, Kyoto-shi, Kyoto, Japan
- 专利权人： 가부시키가이샤 도우사 고가쿠 겐큐쇼
- 当前专利权人： 가부시키가이샤 도우사 고가쿠 겐큐쇼
- 当前专利权人地址： ***, Chudoji-minamimachi, Shimogyo-ku, Kyoto-shi, Kyoto, Japan
- 代理人： 서종완
- 优先权： JPJP-P-2009-151713 2009-06-26
- 国际申请： PCT/JP2010/060443 2010-06-21
- 国际公布： WO2010150730 2010-12-29
- 主分类号： C07K1/06
- IPC分类号： C07K1/06 ; C07K1/14 ; C07K7/06 ; C07K14/00
[Problem] The present invention will be a challenge to provide a novel method of chemically converting a sieve peptide thioester peptide chain.
[MEANS FOR SOLVING PROBLEMS] The present inventors, in the peptide chain, a cysteine residue was noted. Then, the thiol groups of cysteine residues, -C (= X) -R
1 group is introduced, and the other hand, by reacting a compound having a leaving group, which is represented by an organic solvent -NH-C (= Y) NHR 3, a cysteine residue of the N-terminal -NH-C (= Y) to the carboxyl group of the peptide bonds of the side NHR
3 group is added, the peptide bond is cut, and found to be a peptide fragment of the C-terminal side resection. In addition, for the -NH-C (= Y) NHR carbonyl carbon which is bonded by reacting a thiol in the peptide chain from the buffer solution an additional
3 group, -NH-C (= Y) NHR
3 group, the thiol the thiol groups are, by thiol exchange reaction in that the -NH-C (= Y) NHR 3 leaving groups, was found to be converted from a peptide thioester.
公开/授权文献:
- KR1020120039637A 펩티드 티오에스테르체의 제조방법 公开/授权日：2012-04-25