基本信息:
- 专利标题： 스컬캅플라본Ⅱ 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 천식의 예방 또는 치료용 약학적 조성물
- 专利标题（英）：A pharmaceutical compositon containing SkullcapflavoneⅡ or pharmaceutically acceptable salt thereof for the prevention or treatment of asthma
- 专利标题（中）：用于预防或治疗哮喘的药物组合物，其含有标记黄酮II或其药学上可接受的盐作为活性成分
- 申请号：KR1020120044045 申请日：2012-04-26
- 公开(公告)号：KR101515067B1 公开(公告)日：2015-04-27
- 发明人： 안경섭 , 오세량 , 장하영 , 권옥경 , 김두영 , 김정희 , 박미정 , 이형규 , 진영원
- 申请人： 한국생명공학연구원
- 申请人地址： ***, Gwahak-ro, Yuseong-gu, Daejeon, (***-***), Republic of Korea
- 专利权人： 한국생명공학연구원
- 当前专利权人： 한국생명공학연구원
- 当前专利权人地址： ***, Gwahak-ro, Yuseong-gu, Daejeon, (***-***), Republic of Korea
- 代理人： 이원희
- 主分类号： A61K31/045
- IPC分类号： A61K31/045 ; A61K31/05 ; A61K31/122 ; A61P11/06
The present invention weight reduction caused due to the skull Cobb flavone Ⅱ or a pharmaceutically to acceptable salts of a pharmaceutical composition for the prevention or treatment of asthma containing as an active ingredient, specifically, the skull Cobb flavone Ⅱ compounds asthma inhibition and airway can alleviate sensitization, the serum and BAL fluid within the IgE, ovalbumin-specific IgE, interleukin-4, 5, 13, and generation of MMP-9, collagen erosion around the trachea, bronchial inflammation cells It can suppress the invasion and bronchial within mucus and as well as have low liver toxicity, and further, reduce the concentration of TGF-β1, by suppressing the increase in the Smad7 expression and pSmad2 / 3 concentration pharmaceutical for the prevention or treatment of bronchial asthma as an active ingredient of the compositions may be useful.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |