KR101481447B1 방사성 핵종이 표지되고 혈관신생-촉진 단백질 또는 펩티드가, 담지된 고분자 하이드로겔, 이의 제조 방법 및 이를 유효성분으로 포함하는 허혈성 질환의 예방 또는 치료용 약학 조성물
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基本信息:
- 专利标题： 방사성 핵종이 표지되고 혈관신생-촉진 단백질 또는 펩티드가, 담지된 고분자 하이드로겔, 이의 제조 방법 및 이를 유효성분으로 포함하는 허혈성 질환의 예방 또는 치료용 약학 조성물
- 专利标题（英）：Radioisotope-labeled and angiogenesis-promoting protein or peptide-loaded polymeric hydrogel and method for preparing the same, and pharmaceutical composition comprising the same for preventing or treating ischemic disease
- 专利标题（中）：放射性同位素标记和血管生成促进蛋白或加载肽的聚合物水凝胶及其制备方法，以及包含其的药物组合物用于预防或治疗缺血性疾病
- 申请号：KR1020120134425 申请日：2012-11-26
- 公开(公告)号：KR101481447B1 公开(公告)日：2015-01-13
- 发明人： 이창문 , 정환정
- 申请人： 전북대학교산학협력단
- 申请人地址： 전라북도 전주시 덕진구 백제대로 *** (덕진동*가)
- 专利权人： 전북대학교산학협력단
- 当前专利权人： 전북대학교산학협력단
- 当前专利权人地址： 전라북도 전주시 덕진구 백제대로 *** (덕진동*가)
- 代理人： 김순웅
- 主分类号： A61K51/08
- IPC分类号： A61K51/08 ; A61K51/04 ; A61P9/10 ; A61P9/00
The invention radionuclides cover and angiogenesis-related to promote protein or peptide, the supported polymeric hydrogels, their preparation and pharmaceutical compositions for preventing or treating ischemic diseases containing the same as an active ingredient. Polymer hydrogel according to the invention cover a radionuclide to the biodegradable polymer directly to the hydrogel formed upon angiogenesis-by carrying promote protein or peptide, while staying in the polymer hydrogel is integrated lesions gradually angiogenesis-promoting protein or promote a large amount of angiogenesis to be able to release the peptide may prevent the waste of the protein, by using a gamma camera to be able to determine the in vivo distribution to quantify the amount of the particles staying in the area of ischemic diseases and a therapeutic effect It can be predicted. In addition, by emitting radiation from the lesion it can be useful in the treatment of diseases such as ischemic diseases. Therefore, the polymer hydrogel according to the invention are radionuclides and angiogenesis - the therapeutic effect can be expected by promoting protein or peptide at the same time, can improve the therapeutic effects of the lesion bar to evaluate the accumulation of the therapeutic agent quantitatively.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K51/00 | 用于治疗或体内测试用的含有放射性物质的配制品 |
| --------A61K51/02 | .以载体为特征 |
| ----------A61K51/04 | ..有机化合物 |
| ------------A61K51/08 | ...肽，例如蛋白质 |