KR101476095B1 고함량의 카탈폴 유도체를 다량 함유한 산꼬리풀 유래 꼬리풀 신규 정제물 또는 이로부터 분리된 카탈폴 유도체를 유효성분으로 포함하는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
有权
基本信息:
- 专利标题： 고함량의 카탈폴 유도체를 다량 함유한 산꼬리풀 유래 꼬리풀 신규 정제물 또는 이로부터 분리된 카탈폴 유도체를 유효성분으로 포함하는 만성 폐쇄성 폐질환의 예방 또는 치료용 조성물
- 专利标题（英）：a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundunt amount of catapol derivatives, as an active ingredient for preventing or treating chronic obstructive pulmonary disease
- 申请号：KR1020140036245 申请日：2014-03-27
- 公开(公告)号：KR101476095B1 公开(公告)日：2014-12-23
- 发明人： 이용남 , 유지석 , 신대희 , 류병환 , 안경섭 , 오세량 , 이형규 , 신인식 , 김두영 , 권옥경 , 송혁환 , 김승형 , 이수의
- 申请人： 영진약품 주식회사 , 한국생명공학연구원
- 申请人地址： 서울특별시 송파구 올림픽로**다길 ** (신천동)
- 专利权人： 영진약품 주식회사,한국생명공학연구원
- 当前专利权人： 영진약품 주식회사,한국생명공학연구원
- 当前专利权人地址： 서울특별시 송파구 올림픽로**다길 ** (신천동)
- 代理人： 신동인
- 优先权： KR1020130039458 2013-04-10
- 主分类号： A61K36/80
- IPC分类号： A61K36/80 ; A61K31/352 ; A61K31/35 ; A23L1/30
The present invention relates to acid kkoripul extract, fractions thereof, and purified fractions, and compositions for preventing or treating chronic obstructive pulmonary disease comprising the compound as an active ingredient. With the present invention acid kkoripul extract, fraction and its purified fraction according to, inhibiting the expression of a separation from the acid kkoripul compounds Beta 2 receptor enhancing effect is indicated if the standing effectively MUC5AC (oligomeric mucus / gel-forming) to form a mucilage and the molecular expression changes closed cruise by only Th2 cells in experimental induced the expression of IL-4, and COPD caused in the experiment using BALB / c male mice inflammatory immune cells and neutrophil cells involved in Th2 cell differentiation proliferation and production of active suppression, growth inhibition of neutrophil cells, the chemokines involved in the lung cell destruction (chemokines) MIP-2 / CXCL-2, TNF-α, KC / CXCL-1 (Chemokines Gro-α), and CXCL-8, etc. sikimyeo check indicates an anti COPD effect through the inhibition and also, SPF (specific pathogen-free) in an animal experiment using Sprague-Dawley rats, decreases the secretion of IL-1β, IL-6, TNF-α, NF-κB by reducing the activation, by the check suppressing leading cause of MMP-9 expression in COPD it is useful in the prevention or treatment of COPD.
公开/授权文献:
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K36/00 | 含有来自藻类、苔藓、真菌或植物或其派生物，例如传统草药的未确定结构的药物制剂 |
| --------A61K36/18 | .被子植物亚门 |
| ----------A61K36/185 | ..双子叶植物纲 |
| ------------A61K36/80 | ...玄参科 |