基本信息:
- 专利标题： ＵＢＡＰ２를 포함하는 골다공증 진단 및 치료효과 평가용 바이오 마커 조성물
- 专利标题（英）：Biomarker composition comprising UBAP2 for diagnosis and evaluation of clinical therapeutic effect for osteoporosis
- 专利标题（中）：包含UBAP2用于诊断和评估骨质疏松症临床治疗效果的生物标志物组合物
- 申请号：KR1020130013280 申请日：2013-02-06
- 公开(公告)号：KR101463505B1 公开(公告)日：2014-11-19
- 发明人： 정선용 , 진현석 , 김보영 , 정윤석 , 김범택
- 申请人： 아주대학교산학협력단
- 申请人地址： 경기도 수원시 영통구 월드컵로 *** (원천동)
- 专利权人： 아주대학교산학협력단
- 当前专利权人： 아주대학교산학협력단
- 当前专利权人地址： 경기도 수원시 영통구 월드컵로 *** (원천동)
- 代理人： 김순웅
- 优先权： KR1020120011792 2012-02-06
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/12 ; G01N33/15 ; G01N33/68
This invention relates to osteoporosis diagnosis and treatment assessment of biomarkers compositions, methods of screening for osteoporosis induced material using UBAP2, screening methods for osteoporosis treatment substance, and compositions for the prevention or treatment of disease, including osteoporosis, the UBAP2. Results in the blood cells of the osteoporosis cell model to investigate whether osteoporosis according to the expression level of the UBAP2 of the invention, and osteoporosis induced mouse model, and patients measuring the expression level of the UBAP2, each of the models, and expression of UBAP2 in patients this was found to greatly increase the amount was. Therefore, UBAP2 of the present invention may be used as a biomarker that can be generated prediction or diagnosis of osteoporosis, before processing the test substance to the test subject, the induction of osteoporosis by measuring the increase or decrease of UBAP2 expression level after, or prevention or it may be used in the screening method of the material for treatment. Moreover, can be advantageously used to, by measuring the expression level of the blood collected from the patient in a UBAP2 determine the prognosis of the patient for diagnosis and treatment of osteoporosis, osteoporosis at the molecular level.
公开/授权文献:
- KR1020130101998A ＵＢＡＰ２를 포함하는 골다공증 진단 및 치료효과 평가용 바이오 마커 조성물 公开/授权日：2013-09-16
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K48/00 | 含有插入到活体细胞中的遗传物质以治疗遗传病的医药配制品；基因治疗 |