基本信息:
- 专利标题： 스페르민 공중합체 및 이를 핵산 전달체로 이용하는 유전자 치료
- 专利标题（英）：Spermine copolymer and gene therapy using the same as a gene carrier
- 专利标题（中）：精胺共聚物和使用与基因载体相同的基因治疗
- 申请号：KR1020120030815 申请日：2012-03-26
- 公开(公告)号：KR101459185B1 公开(公告)日：2014-11-07
- 发明人： 조명행 , 강호림
- 申请人： 서울대학교산학협력단
- 申请人地址： 서울특별시 관악구 관악로 * (신림동)
- 专利权人： 서울대학교산학협력단
- 当前专利权人： 서울대학교산학협력단
- 当前专利权人地址： 서울특별시 관악구 관악로 * (신림동)
- 代理人： 손민
- 优先权： KR1020110027191 2011-03-25
- 主分类号： C08G83/00
- IPC分类号： C08G83/00 ; C08F20/34 ; A61K31/13 ; A61K48/00
The invention spermine (spermine) relates to a gene therapy using this copolymer and a nucleic acid delivery carrier. Spermine co-polymers of the present invention exhibits a high binding capacity for by copolymerizing a spermine (spermine, SPE) using a linker compound containing two or more hydroxyl groups, DNA, etc. therapeutic nucleic acid, DNA from nucleolytic enzymes by an effective protection, and not only exhibit physical and chemical properties suitable for use as nucleic acid delivery carrier, the hydroxyl group of the linker to prevent the access and aggregation caused thereby in the other blood protein improves the blood stability of the nucleic acid delivery carrier, in vitro and shows a very low cell toxicity in vivo, the transduction efficiency can be very high, as the nucleic acid delivery carrier useful for gene therapy.
公开/授权文献:
- KR1020120111719A 스페르민 공중합체 및 이를 핵산 전달체로 이용하는 유전자 치료 公开/授权日：2012-10-10
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C08 | 有机高分子化合物；其制备或化学加工；以其为基料的组合物 |
| ----C08G | 用碳—碳不饱和键以外的反应得到的高分子化合物 |
| ------C08G83/00 | 在C08G2/00到C08G81/00组中不包含的高分子化合物 |