基本信息:
- 专利标题： ＲＮＡ 간섭을 유도하는 핵산 분자 및 그 용도
- 专利标题（英）：Nucleic Acid Molecule Inducing RNA interference and the Use Thereof
- 专利标题（中）：核酸分子诱导RNA干扰及其用途
- 申请号：KR1020110090665 申请日：2011-09-07
- 公开(公告)号：KR101328568B1 公开(公告)日：2013-11-13
- 发明人： 이동기
- 申请人： 성균관대학교산학협력단
- 申请人地址： 경기도 수원시 장안구 서부로 **** (천천동, 성균관대학교내)
- 专利权人： 성균관대학교산학협력단
- 当前专利权人： 성균관대학교산학협력단
- 当前专利权人地址： 경기도 수원시 장안구 서부로 **** (천천동, 성균관대학교내)
- 代理人： 이처영
- 优先权： KR1020100103701 2010-10-22; KR1020110062504 2011-06-27
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/7105 ; A61K48/00 ; A61P35/00
The present invention relates to nucleic acid molecules and their use to induce RNAi of a new structure, and more specifically to a target nucleic acid (target nucleic acid) complementary to a partial region of the first strand of 24 ~ 121nt length, including, the first the target nucleic acid of a first strand complementary to a partial area with a new structure in which to have a structure consisting of a second strand of 13 ~ 21nt length increases the inhibition of expression efficiency of a target gene has a region which forms a complementary binding nucleic acid molecule and It relates to a method of inhibiting expression of a target gene using the same. The nucleic acid molecular structure according to the present invention is a gene to increase the suppression efficiency or, or antisense DNA, antisense RNA, ribozyme, there is the effect that occurs a affinity improved or synergistic cleavage of the same target gene with a siRNA by the introduction of DNAzyme gene of It may increase the efficiency of suppression. In addition, it is possible to extend the duration of the efficiency of gene suppression by using a nucleic acid molecule according to the invention. This nucleic acid molecule to induce RNAi according to the present invention is useful it can be used like cancer or viral infections using siRNA to replace conventional siRNA molecules.
公开/授权文献:
- KR1020120042645A ＲＮＡ 간섭을 유도하는 핵산 분자 및 그 용도 公开/授权日：2012-05-03