KR101300540B1 인간 글루코키나제 돌연변이체 코딩 유전자, 이에 의하여 코딩된 효소, 재조합 벡터 및 숙주, 이의 약학적 조성물 및 용도, 및 질병의 예방 및 치료 방법
有权
基本信息:
- 专利标题： 인간 글루코키나제 돌연변이체 코딩 유전자, 이에 의하여 코딩된 효소, 재조합 벡터 및 숙주, 이의 약학적 조성물 및 용도, 및 질병의 예방 및 치료 방법
- 专利标题（英）：Gene encoding human glucokinase mutant, enzyme encoded by the same, recombinant vectors and hosts, pharmaceutical compositions and uses thereof, methods for treating and preventing diseases
- 专利标题（中）：编码人类GLUCOKINASE突变体，酶编码的酶，重组载体和宿主，药物组合物及其用途，治疗和预防疾病的方法
- 申请号：KR1020117017931 申请日：2010-01-06
- 公开(公告)号：KR101300540B1 公开(公告)日：2013-09-02
- 发明人： 후앙하이동
- 申请人： 후앙 하이동
- 申请人地址： Room ***, Bldg. *, No. ** Xizhimen North Street, Haidian District, Beijing ******, CHINA
- 专利权人： 후앙 하이동
- 当前专利权人： 후앙 하이동
- 当前专利权人地址： Room ***, Bldg. *, No. ** Xizhimen North Street, Haidian District, Beijing ******, CHINA
- 代理人： 특허법인신성
- 优先权： CN2009100000871 2009-01-07
- 国际申请： PCT/CN2010/070038 2010-01-06
- 国际公布： WO2010078842 2010-07-15
- 主分类号： C12N15/52
- IPC分类号： C12N15/52 ; C12N15/63 ; C12N15/85 ; A61K48/00
According to the present invention to provide a bar human glucokinase mutant encoding gene, which is SEQ ID NO: 2 nucleotide sequence represented by; Or transcription reading frames in SEQ ID NO: 2 as shown is the nucleotide sequence of the 487 to the 1884 position of the transcription reading frame to by coding as the same amino acid sequence of the coding and transcription reading frames other than the remainder of SEQ ID NO: the nucleotide sequence shown in SEQ ID NO: 2 has the same nucleotide. Recombinant vector, a method host containing the recombinant vector, the pharmaceutical compositions containing them, their use, and using them to prevent and treat disease in the present invention, which again comprises a glucokinase mutants, the gene in which the gene is expressed It provides. Since the activity of the glucokinase gene is expressed in the mutant to the invention is higher than the wild-type glucokinase, provides a new method for the prevention and treatment, in particular the prevention and treatment of diabetes, blood sugar control or carbohydrate metabolism disorders.