基本信息:
- 专利标题： 인간 콜린 아세틸트랜스퍼라아제를 발현하는 인간 신경줄기세포 및 이의 용도
- 专利标题（英）：Human Neural Stem Cell Expressing Human Choline Acetyltransferase and Its Use
- 专利标题（中）：人类神经干细胞表达人胆碱乙酰转移酶及其用途
- 申请号：KR1020100098234 申请日：2010-10-08
- 公开(公告)号：KR101226702B1 公开(公告)日：2013-01-25
- 发明人： 김윤배 , 김승업
- 申请人： 충북대학교 산학협력단
- 申请人地址： 충청북도 청주시 서원구 충대로 * (개신동)
- 专利权人： 충북대학교 산학협력단
- 当前专利权人： 충북대학교 산학협력단
- 当前专利权人地址： 충청북도 청주시 서원구 충대로 * (개신동)
- 代理人： 양부현; 김승진
- 主分类号： C12N5/0797
- IPC分类号： C12N5/0797 ; C12N5/10 ; C12N15/54 ; C12N15/85
The present invention is a human choline acetyl transferase dehydratase (ChAT) is transformed with the vector containing the coding nucleotide sequence, human neural stem cells, the pharmaceutical composition for Alzheimer's disease therapy containing the same, and learning capacity or memory capacity to express the ChAT enzyme the present invention relates to compositions for improving cognitive dysfunction such. By when the human neural stem cells genetically modified to express the human ChAT is implanted in the brain of Alzheimer's disease animal model has been successfully coupled to the host brain tissue were differentiated into normal nerve cells, expressing ChAT stable, acetylcholine was reduced the concentration was restored to normal levels. In addition, it compromised cognitive function and improved the cognitive function of Alzheimer's disease animal models. Therefore, it chats expression of human neural stem cells of the invention can be developed as a drug for improvement of cognitive function disorders such as learning ability or memory skills due to the disease and the treatment of Alzheimer's disease applications.
公开/授权文献:
- KR1020120036506A 인간 콜린 아세틸트랜스퍼라아제를 발현하는 인간 신경줄기세포 및 이의 용도 公开/授权日：2012-04-18