基本信息:
- 专利标题： 전리방사선을 이용한 마우스의 사이토카인 조절방법
- 专利标题（英）：Regulation of cytokine secretion by chronic low-dose ionizing radiation
- 专利标题（中）：通过慢性低剂量电离辐射调节细胞因子分泌
- 申请号：KR1020100112926 申请日：2010-11-12
- 公开(公告)号：KR101225378B1 公开(公告)日：2013-01-22
- 发明人： 김희선 , 양광희 , 강유미
- 申请人： 한국수력원자력 주식회사
- 申请人地址： 경상북도 경주시 양북면 불국로 ****
- 专利权人： 한국수력원자력 주식회사
- 当前专利权人： 한국수력원자력 주식회사
- 当前专利权人地址： 경상북도 경주시 양북면 불국로 ****
- 代理人： 남진우; 배철우
- 主分类号： A61N5/10
- IPC分类号： A61N5/10 ; A61N5/00
The present invention relates to a cytokine regulating method of the mouse using ionizing radiation, a) and the step of classifying the experimental mice with low dose of ionizing radiation irradiated group and high dose ionizing irradiation group, b) classified into the low-dose ionizing radiation irradiated group the mouse comprising the steps of a cumulative dose of ionizing radiation of low dose irradiation on 0.2Gy so that, c) the steps of the high dose and the accumulated dose of the ionizing radiation dose in mice sorted by ionizing radiation is irradiated such that the irradiated group 2Gy , d) comprising the steps of: by checking the metabolism, such as weight changes of mice in the two groups of the ionizing radiation in said respective leakage dose irradiation, for changes in the metabolism of the irradiation of ionizing radiation, e) of the two groups Check the mouse number of each white blood cell, red blood cells, platelets and confirming a change in the immune cell according to the irradiation of ionizing radiation, f) by extraction the individual spleen cells in mice of the two groups to determine the ratio of immune cells step and, g) comprises the step to verify the production of a number of types of cytokine. This invention has the effect that by irradiating the ionizing radiation of a low dose to be able to control the release of the cytokine, can be augmented by the immune system of the mice to treat diseases such as cancer and autoimmune disease without the other side effects.
公开/授权文献:
- KR1020120051478A 전리방사선을 이용한 마우스의 사이토카인 조절방법 公开/授权日：2012-05-22
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61N | 电疗；磁疗；放射疗；超声波疗 |
| ------A61N5/00 | 放射疗 |
| --------A61N5/10 | .X射线治疗法，γ射线治疗法；粒子照射疗法 |