The invention bioactivity of apatite, and relates to a production method thereof, and more particularly, to a heat treatment after ion exchange from an aqueous solution containing the bone chlorine ion of the animal to give the chloride / hydroxide double structure type apatite, and wherein the chloride / hydroxide double structure type and was immersed in a solution supersaturated with the apatite on the apatite dissolution chloride apatite surface is gwapohwado increases to the apatite in the solution by the release of calcium and hydroxide ions low crystalline carbonate apatite is low-crystalline carbon is formed in the hydroxide apatite surface / double hydroxide structure type production of bioactive apatite to obtain apatite and to a method of bioactive apatite prepared by the above method. Bone graft substitute containing a bioactive apatite according to the present invention is to cause an immune response when transplanted human body, facilitating the attachment and differentiation and bone cells, and promotes bone formation, there is an effect of improving the body conformance. Further, when to be immersed in a solution supersaturated with respect to apatite, low crystalline carbonate apatite nano-size is formed on the surface drastically bone conductivity to increase the adhesion efficiency, such as the specific surface area is increased, and various peptides, proteins, growth factors It has the effect of improving. Bioactivity, apatite hydroxide, apatite chloride, low crystalline apatite carbonate