基本信息:
- 专利标题： 신규한 디페닐 아미드 유도체, 그의 제조방법 및 이를포함하는 약학 및 화장료 조성물
- 专利标题（英）：Novel diphenyl amide derivatives, the process for preparing them and the pharmacological composition and the cosmetic composition containing them
- 专利标题（中）：신규한디페닐아미드유도체，그의제조방법및이를포함하는약학및화장료조성물
- 申请号：KR1020000078490 申请日：2000-12-19
- 公开(公告)号：KR100407640B1 公开(公告)日：2003-12-01
- 发明人： 김선여 , 김상희 , 최상윤 , 김호철 , 석경호 , 황재성 , 이병곤
- 申请人： 김선여 , 최상윤 , 석경호 , 김상희 , 김호철 , 주식회사 아모레퍼시픽그룹
- 申请人地址： 서울특별시 강남구 도곡로**길 **, ***동 ***호 (대치동, 대치삼성아파트)
- 专利权人： 김선여,최상윤,석경호,김상희,김호철,주식회사 아모레퍼시픽그룹
- 当前专利权人： 김선여,최상윤,석경호,김상희,김호철,주식회사 아모레퍼시픽그룹
- 当前专利权人地址： 서울특별시 강남구 도곡로**길 **, ***동 ***호 (대치동, 대치삼성아파트)
- 代理人： 신동인
- 主分类号： C07C233/88
- IPC分类号： C07C233/88
摘要：
PURPOSE: Provided are novel diphenyl amide derivatives which have tyrosinase inhibiting and lightening effects, a production method thereof, and a pharmaceutical and cosmetic composition containing the same. CONSTITUTION: The diphenyl amide derivatives have a chemical structure represented by the formula I, in which R1 to R5 are independently hydrogen, halogen, C1-4 alkyl, C3-6 cycloalkyl or C1-4 alkoxy, R6 to R10 are independently hydrogen or C1-4 alkoxy, and R11 is hydrogen, C1-4 alkyl, C3-6 cycloalkyl or C1-4 alkoxy. The diphenyl amide derivatives are prepared by reacting a compound of formula II with triphenylphosphine in the presence of trihaloacetonitrile to obtain a compound of formula III, and reacting the compound of formula III with a compound of formula IV in a polar solvent using tertiary amine as a catalyst. In the formulae III and IV, x is a halogen atom and R1 to R11 are the same as defined above.
摘要（中）：
目的：提供具有酪氨酸酶抑制和增亮作用的新型二苯基酰胺衍生物及其生产方法，以及含有其的药物和化妆品组合物。 构成：二苯基酰胺衍生物具有由式I表示的化学结构，其中R1至R5独立地为氢，卤素，C1-4烷基，C3-6环烷基或C1-4烷氧基，R6至R10独立地为氢或C1 -4烷氧基，并且R 11是氢，C 1-4烷基，C 3-6环烷基或C 1-4烷氧基。 二苯基酰胺衍生物通过使式II化合物与三苯基膦在三卤乙腈存在下反应得到式III化合物，并使式III化合物与式IV化合物在极性溶剂中反应，使用叔胺作为 催化剂。 在式III和IV中，x是卤素原子，并且R1至R11与以上定义的相同。
公开/授权文献:
- KR1020020049340A 신규한 디페닐 아미드 유도체, 그의 제조방법 및 이를포함하는 약학 및 화장료 조성물 公开/授权日：2002-06-26
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C233/00 | 羧酸酰胺 |
| --------C07C233/88 | .羧酰胺基的氮原子连接在非环碳原子和连在至少有1个邻位氢已被取代的六元芳环的碳原子上 |