Aryl amides of formula (I) may be used to during as inhibitors of tumor necrosis factor α, kahek, inhibit endotoxic shock and retrovirus replication. (I) Wherein Ar is (i) unsubstituted, linear C 1 to 12 of the side chain, or cyclic alkyl; (Ii) having a carbon number of 1-substituted straight chain of 1 to 12, branched or cyclic alkyl; (Iii) phenyl; (Iv) each nitro independently, cyano, trifluoromethyl, carboxylic chopping epoxy, carboxylic bome butoxy, carbo propoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, substituted amino, substituted phenyl from the group consisting of 1 to 10 carbon atoms, alkoxy having 1 to 10 carbon atoms, or halo, with one or more substituents selected; (V) heterocycle; Or (vi) each mutually independently represent a nitro, cyano, trifluoromethyl, carboxylic chopping ethoxy, carboxylic bome butoxy, carbo propoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, C 1 -C 10 alkyl, C 1 -C 10 alkoxy, or a heteroaryl ring substituted with at least one substituent selected from halo; R is -H, a C 1 -C 10 _{alkyl, -CH 2 OH, -CH 2 CH} 2 OH or -CH ₂ COZ a, where Z is alkoxy having 1 to 10 carbon atoms and benzyl oxy or NHR ^1, where R ¹ is H or alkyl having 1 to 10, Y is i) unsubstituted and each mutually independently represent a nitro, cyano, trifluoromethyl, carboxylic chopping ethoxy, carboxylic bome butoxy, carbo propoxy, acetyl, carbamoyl together, acetoxy, carboxy, hydroxy, amino, phenyl or heterocyclic substituted by at least one substituent selected from the group consisting of alkoxy, or halo-C 1 -C 10 alkyl, C 1 -C 10, or ii) naphthyl to be.