基本信息:
- 专利标题： 細胞内物質移送システムおよびその利用
- 专利标题（英）：JPWO2017131242A1 - Intracellular material transport system and its use
- 申请号：JP2017003880 申请日：2017-01-27
- 公开(公告)号：JPWO2017131242A1 公开(公告)日：2018-11-22
- 发明人： 西村 紳一郎
- 申请人： 国立大学法人北海道大学
- 申请人地址： 北海道札幌市北区北8条西5丁目
- 专利权人： 国立大学法人北海道大学
- 当前专利权人： 国立大学法人北海道大学
- 当前专利权人地址： 北海道札幌市北区北8条西5丁目
- 代理人： 特許業務法人特許事務所サイクス
- 优先权： JP2016015760 2016-01-29
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K31/44 ; A61P43/00 ; A61P35/00 ; A61K47/54 ; C12N9/99
The present invention is a composite comprising a phospholipid pseudo substance represented by the following general formula, which is supported on the surface of the nanoparticles and the nanoparticles lysosomal enzyme inhibitors represented by (A) or a kinase inhibitor and the following general formula (B) body on.
In the general formula (A), n1 is an integer from 2 to 30, n2 is an integer of 2 to 30, -S- terminal is nanoparticles supported
site, R 10 is a suicide substrate site or kinase inhibitory site is there.
In the general formula (B), n3 is an integer ranging from 2 to 30, -S- ends are nanoparticles supported site. The invention is also directed to pharmaceutical and carry efficiently endolysosomes provides an anti-cancer agent that utilizes a system and this system is rich in versatility can function at low concentrations to lysosomal enzymes.
公开/授权文献:
- JP2018110755A 商品陳列システム 公开/授权日：2018-07-19