A has the tramadol or immediate release part and the sustained-release part containing a pharmaceutically acceptable salt thereof, persistence with in a few excellent release characteristics pH dependent stable in immediate a and initial dissolution providing a solid pharmaceutical formulation.
The present invention has an immediate release portion and a sustained release part, containing a salt of tramadol or a pharmaceutically acceptable active ingredient both parts, partially pregelatinized as an additive in the rapidly releasing portion about sustained solid pharmaceutical preparation characterized by containing starch and excipients. The formulations according to the invention, for rapid pain relief, quickly reaching effective blood concentration after administration, a depot preparation then can be sustained efficacy over a long period of time, rapid stable pH-independent It indicates an initial elution behavior is even more practical as a preparation having a sufficient strength to wear and cracking and chipping does not occur in coating tablets.