基本信息:
- 专利标题： 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法
- 专利标题（英）：Method for producing a novel acetoacetyl-CoA reductase and an optically active alcohol
- 申请号：JP2005515359 申请日：2004-11-10
- 公开(公告)号：JPWO2005044973A1 公开(公告)日：2007-11-29
- 发明人： 川野 茂 , 茂 川野 , 八十原 良彦 , 良彦 八十原
- 申请人： 株式会社カネカ
- 专利权人： 株式会社カネカ
- 当前专利权人： 株式会社カネカ
- 优先权： JP2003380987 2003-11-11
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N20060101 ; C12N1/21 ; C12N9/02 ; C12N9/04 ; C12P7/02 ; C12P7/04 ; C12P7/22 ; C12P7/42 ; C12P7/62 ; C12P13/00 ; C12P41/00
The present invention, (R)-3-hydroxy pentane nitrile, providing convenient preparation of optically active alcohols of optically active 3-hydroxybutanoic acid ester and optically active 1-phenylethanol derivatives, as well as the optically active alcohols, in particular ( and to provide useful new enzymes for the production of R) -3- hydroxypentanenitrile. The present invention is 3-keto pentane nitrile to asymmetrically reduce an optical purity 99% e. e. More (R)-3-novel acetoacetyl-CoA reductase can generate a hydroxypentanenitrile; 3-keto pentanenitrile each acetoacetate and 1-phenyl-ethanone derivatives, the novel enzymes or known acetoacetyl CoA reductase enzyme is allowed to act, a corresponding method for producing an optically active alcohol.