基本信息:
- 专利标题： 遺伝子導入された樹状細胞の製造方法
- 专利标题（英）：Method for producing a transgenic dendritic cells
- 申请号：JP2005515163 申请日：2004-10-29
- 公开(公告)号：JPWO2005042737A1 公开(公告)日：2007-05-10
- 发明人： 慎士 岡野 , 慎士 岡野 , 米満 吉和 , 吉和 米満 , 居石 克夫 , 克夫 居石 , 智子 柴田 , 智子 柴田 , 長谷川 護 , 護 長谷川
- 申请人： 株式会社ディナベック研究所
- 专利权人： 株式会社ディナベック研究所
- 当前专利权人： 株式会社ディナベック研究所
- 优先权： JP2003374808 2003-11-04; JP2004187028 2004-06-24
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K35/28 ; A61K39/00 ; A61P35/00 ; C12N5/10 ; C12N15/86
The present invention includes the step of minus-strand RNA virus is contacted with dendritic cells, provides a method for introducing genes into dendritic cells. The present invention is a method for producing dendritic cells gene has been introduced, the method comprising the step of contacting a minus-strand RNA viruses and dendritic cells. The present invention were prepared by this method, genes are introduced to provide a dendritic cell. The invention further comprises the step of contacting a minus-strand RNA viruses and dendritic cells, provides a method of activating dendritic cells. The present invention enables efficient gene delivery to dendritic cells. Dendritic cells transfected with the antigen gene or cytokine gene is useful as a vaccine.