formula

(Wherein, ^{R 1} represents a hydrogen _{atom, C 1-4 alkyl, C 1-4} alkoxy group or a halogen atom, A is _{C 1-10} alkylene radical or formula

(Wherein, m, n and p are each an integer of 0 to 4.) Represents a group represented by, R represents N, _{N-di-C 1-6} alkylamino group, a dioxanyl _{group, C 1-4} a dioxanyl group substituted with an alkyl _{group, C 1-4} alkoxy _{C 1-4} alkoxy group, or a group represented by formula

(Wherein, s and t each represent an integer from 1 to 4, B is substituted with a methylene group, an oxygen atom, a sulfur atom, a nitrogen atom, a nitrogen atom substituted with a C _1-4 alkyl group, a phenyl group represents nitrogen atom or a nitrogen atom substituted with a benzyl group, R ² represents a hydrogen atom or a C _1-4 alkyl group, r represents a group represented by.) represents an integer of 0 to 2. N- hydroxy formamidine derivative or a pharmaceutically acceptable salt thereof represented by).
The present invention is to provide an agent that inhibits renal microvascular contraction in major organs cerebrovascular like, extended action, the production enzyme 20-HETE that are involved in cell proliferation inducing action and the like.