基本信息:
- 专利标题： NITROTRIAZOLE DERIVATIVE AND PRODUCTION THEREOF
- 申请号：JP8763487 申请日：1987-04-09
- 公开(公告)号：JPS63253077A 公开(公告)日：1988-10-20
- 发明人： NAGAO YOSHIMITSU , ABE MITSUSACHI , KAGITANI TSUTOMU , SANO SHIGEKI , OCHIAI MASAHITO , FUJI KAORU , NISHIMOTO SEIICHI , SHIBAMOTO YUTA , MORI TOMOYUKI , MURAYAMA CHIEKO
- 申请人： NAGAO YOSHIMITSU , ABE MITSUSACHI , KAGITANI TSUTOMU
- 专利权人： NAGAO YOSHIMITSU,ABE MITSUSACHI,KAGITANI TSUTOMU
- 当前专利权人： NAGAO YOSHIMITSU,ABE MITSUSACHI,KAGITANI TSUTOMU
- 优先权： JP8763487 1987-04-09
- 主分类号： C07D249/14
- IPC分类号： C07D249/14 ; A61K31/41 ; A61P35/00
摘要：
NEW MATERIAL:The 3-nitro-1,2,4-triazole derivative of formula I [R is group of formula II (X is group of formula III, formula IV, formula V or formula VI) bonded to 1- or 2-N of triazole ring)]. EXAMPLE:The compound of formula I wherein R is group of formula II bonded to the 1-position of triazole ring and X is group of formula III. USE:A drug. A radiosensitizer for hypoxic cell. It has low toxicity. PREPARATION:The compound of formula I can be produced by reacting 3- nitro-1,2,4-triazole with propylene oxide, reacting the resultant compound with phenyl chlorocarbonate and reacting the obtained compound of formula VII (R is group of formula VIII bonded to 1- or 2-N atom of triazole ring) with an amine selected from N-aminopropylmorpholine, N-aminoethylpiperidine, 1-piperazineethanol and 4-piperidinopiperidine in a solvent such as methylene chloride at room temperature.
公开/授权文献:
- JPS63199340U 公开/授权日：1988-12-22
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D249/00 | 杂环化合物，含五元环，有3个氮原子作为仅有的杂环原子 |
| --------C07D249/02 | .不与其他环稠合 |
| ----------C07D249/04 | ..1,2,3-三唑；氢化1,2,3-三唑 |
| ------------C07D249/10 | ...有杂原子或有以3个键连接杂原子，其中最多以1个键连接卤素的碳原子，例如酯基或腈基，直接连在环碳原子上 |
| --------------C07D249/14 | ....氮原子 |