基本信息:
- 专利标题： POLYPRENYL COMPOUND
- 申请号：JP5054485 申请日：1985-03-15
- 公开(公告)号：JPS61210050A 公开(公告)日：1986-09-18
- 发明人： NAKAMOTO KOJI , SUZUKI TAKESHI , ABE SHINYA , HAYASHI KENJI , KAJIWARA SHOJI , YAMATSU ISAO , OTSUKA KAZUMASA , SHIOJIRI HIROYUKI
- 申请人： EISAI CO LTD
- 专利权人： EISAI CO LTD
- 当前专利权人： EISAI CO LTD
- 优先权： JP5054485 1985-03-15
- 主分类号： A61K31/16
- IPC分类号： A61K31/16 ; A61K31/165 ; A61K31/19 ; A61P3/06 ; A61P9/10 ; C07C51/00 ; C07C57/30 ; C07C57/42 ; C07C61/39 ; C07C63/04 ; C07C63/64 ; C07C67/00 ; C07C233/17 ; C07C233/23 ; C07C233/69 ; C07C237/08 ; C07C237/20 ; C07C237/22
摘要：
NEW MATERIAL:The polyprenyl compound of formula I [all of A, B, Y and Z are H, or A and B or Y and Z together form a single bond; n is 0-2; X is group of formula II (both K and L are H or K and L together form a single bond), CH2 or (CH2)2; m is 0 or 1; R is OH, group of formula III (R and R are H or lower alkyl; p is 1 or 2), NH-(CH2)q-OH (q is 1 or 2), etc.] and its salt. EXAMPLE:4-(2',6',10'-Trimethylundecyl)phenylacetic acid. USE:It has excellent hypocholesteric action, and is useful as an hypocholesteric agent and remedy for arteriosclerosis. PREPARATION:A compound of formula I wherein m is 0 and R is OH can be produced, e.g. by reacting the compound of formula IV with the compound of formula V (n is 0-2) in the presence of a catalyst, is a solvent at room temperature -100 deg.C, and hydrolyzing the reaction product.
公开/授权文献:
- JPH0629218B2 公开/授权日：1994-04-20
信息查询:
EspacenetIPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/16 | .酰胺，例如异羟肟酸 |