基本信息:
- 专利标题： 5-FLUOROURACIL DERIVATIVE AND MEDICINAL DRUG PREPARATION CONTAINING SAME
- 申请号：JP4287085 申请日：1985-03-06
- 公开(公告)号：JPS61204171A 公开(公告)日：1986-09-10
- 发明人： WAKABAYASHI TOSHIO , OZAWA SHINJI , KATAYAMA HAJIME
- 申请人： TERUMO CORP
- 专利权人： TERUMO CORP
- 当前专利权人： TERUMO CORP
- 优先权： JP4287085 1985-03-06
- 主分类号： C07D239/553
- IPC分类号： C07D239/553 ; A61K31/505 ; A61P7/02 ; A61P35/00 ; C07D239/54
摘要：
NEW MATERIAL:The 5-fluorouracil derivative of formula (R is acyl derived from triene higher fatty acid or pentaene higher fatty acid). EXAMPLE:1-(alpha-Linoleylaminomethylcarbamoyl)-5-fluorouracil. USE:A carcinostatic agent and platelet coagulation inhibitor. PREPARATION:The objective compound of formula is produced by reacting 5-fluorouracil (5-FU) with the compound of formula R-NHCH2CO2H in a solvent such as dimethylformamide, dioxane, etc., in the presence of diphenylphos phorylazide. The compound exhibits an antitumor activity (carcinostatic activity) comparable to or higher than 5-FU, and has lower toxicity than 5-FU. It has strong platelet coagulation inhibiting activity which cannot be found in 5-FU. It is administered in a dose of preferably about 1-3g daily for adults.
公开/授权文献:
- JPH0530833B2 公开/授权日：1993-05-11
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D239/00 | 杂环化合物，含1,3-二嗪环或氢化1,3-二嗪环 |
| --------C07D239/02 | .不与其他环稠合 |
| ----------C07D239/06 | ..环原子间或环原子与非环原子间有1个双键 |
| ------------C07D239/28 | ...有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子，直接连在环碳原子上 |
| --------------C07D239/32 | ....1个氧、硫或氮原子 |
| ----------------C07D239/52 | .....两个氧原子 |
| ------------------C07D239/54 | ......以双键连接的氧原子或未被取代的羟基 |
| --------------------C07D239/545 | .......有其他杂原子或有以3个键连杂原子、最多以1个键连卤素的碳原子直接连在环碳原子上 |
| ----------------------C07D239/553 | ........有卤原子或硝基直接连在环碳原子上，例如氟尿嘧啶 |