基本信息:
- 专利标题： Preparation of anthranilic acid derivative
- 专利标题（中）：壬酸衍生物的制备
- 申请号：JP11810283 申请日：1983-07-01
- 公开(公告)号：JPS5970655A 公开(公告)日：1984-04-21
- 发明人： SATOU TOSHIO , AOYANAGI SAKAE , KATOU ATSUYUKI
- 申请人： Nippon Redarii Kk
- 专利权人： Nippon Redarii Kk
- 当前专利权人： Nippon Redarii Kk
- 优先权： JP11810283 1983-07-01
- 主分类号： C07C231/00
- IPC分类号： C07C231/00 ; A61K31/195 ; A61K31/196 ; A61P37/08 ; C07C67/00 ; C07C231/10 ; C07C231/16 ; C07C235/38
摘要：
PURPOSE: To obtain the titled compound useful as an antiallergic agent in high yield, by reacting 2-methyl-3,1-benzoxazin-4-one with 3,4-dimethoxybenzaldehyde in the molten state under solventless conditions.
CONSTITUTION: 2-Methyl-3,1-benzoxazin-4-one of formula I is reacted with 3,4- dimethoxybenzaldehyde of formula II at 150W220°C, preferably about 200°C, for 30minW5hr, preferably 3hr, under solventless conditions to give the aimed substance N-(trans-3,4-dimethoxycinnamoyl)anthranilic acid of formula III. The compound of formula I is used in an amount of 0.5W2mol, preferably 1W1.5mol, based on one mole compound of formula II.
COPYRIGHT: (C)1984,JPO&Japio
摘要（中）：
CONSTITUTION: 2-Methyl-3,1-benzoxazin-4-one of formula I is reacted with 3,4- dimethoxybenzaldehyde of formula II at 150W220°C, preferably about 200°C, for 30minW5hr, preferably 3hr, under solventless conditions to give the aimed substance N-(trans-3,4-dimethoxycinnamoyl)anthranilic acid of formula III. The compound of formula I is used in an amount of 0.5W2mol, preferably 1W1.5mol, based on one mole compound of formula II.
COPYRIGHT: (C)1984,JPO&Japio
目的：通过2-甲基-3,1-苯并恶嗪-4-酮与3,4-二甲氧基苯甲醛在无溶剂条件下在熔融状态下反应，得到高活性的抗过敏药物。 构型：将式I的2-甲基-3,1-苯并恶嗪-4-酮与式II的3,4-二甲氧基苯甲醛在150-220℃，优选约200℃下反应30分钟-5小时，优选 3小时，在无溶剂条件下，得到式III的目标物质N-（反式-3,4-二甲氧基肉桂酰基）邻氨基苯甲酸。 基于一摩尔式II化合物，式I化合物的用量为0.5-2mol，优选1-1.5mol。
公开/授权文献:
- JPH0460982B2 公开/授权日：1992-09-29